Born on January 27, 1930 in Santiago de Chile, Guillermo Núñez entered the Academy of Spanish Letters of the National Institute in 1947. In 1953 he studied at the Arsenal Library and the Opera in Paris. Representative of Chile at the Congress of the Hague Theater Institute. In Paris he designed the sets for "Uncle Vania" by Anton Chekhov. Returning to Santiago de Chile, he resumes his professorship at the Theater School and  work as a designer at the Experimental Theater. He wrote a book about  theater decoration that would only be published in 1967.

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Guillermo Nuñes is a multifaceted artist, who throughout his career has dedicated himself to different creative fields, seeking points of convergence and integration of disciplines. He has developed painting, engraving, serigraphy, photo-serigraphy, graphics, installations and object art, with themes that relate to historical events, wars, disputes and personal experiences, showing and condemning violence and human destruction.He has also worked designing costumes and scenographies for theater, opera and ballet, in Chile and abroad. He has participated in the production of films, posters and murals with political messages, as well as his participation in the Experimental Theater of the University of Chile and teaching theater at the University of Chile.

His work is part of important public and private collections, including: The Museo de la Solidaridad Salvador Allende, Museo de Arte Moderno de Bogotá, Bogotá, Colombia, Museo de Arte Moderno de Chiloé,  Museum of Modern Art MoMA, New York, USA; José Luis Cuevas Museum, Mexico City, Mexico; National Museum of Fine Arts, Santiago de Chile, Chile; Museum of Contemporary Art, Santiago de Chile, Chile; Pushkin Museum, Moscow, Russia; Museum of Contemporary Art of Latin America, Washington,USA . Reina Sofía National Art Center Museum, Madrid. Spain; Oakland Art Museum, Oakland, California, USA;  Préfecture de La Seine-Saint -Denis, Bobigny, France; The Heller Foundation, Washington, United States; Wilhelm-Hack-Museum, Ludwigshafen, Germany.